TRNK guanozin-2'-O-metiltransferaza
(Preusmjereno sa stranice TRNA (guanosine18-2'-O)-methyltransferase)
| TRNK guanozin-2'-O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.34 | ||||||||
| CAS broj | 37257-01-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK guanozin-2'-O-metiltransferaza (EC 2.1.1.34, tRNK (Gm18) 2'-O-metiltransferaza, tRNK (Gm18) metiltransferaza, TrmH, SpoU) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanozin18-2'-O)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanozin18 u tRNK S-adenozil-L-homocistein + 2'-O-metilguanozin18 u tRNK
Ovaj enzim katalizuje metilaciju guanozina18 unutar tRNK.
Reference[uredi | uredi kod]
- ↑ Gefter, M.L. (1969). „The in vitro synthesis of 2′-O-methylguanosine and 2-methylthio 6N (γ,gamma-dimethylallyl) adenosine in transfer RNA of Escherichia coli”. Biochem. Biophys. Res. Commun. 36: 435-441. PMID 4898378.
- ↑ Kumagai, I., Watanabe, K. and Oshima, T. (1980). „Thermally induced biosynthesis of 2′-O-methylguanosine in tRNA from an extreme thermophile, Thermus thermophilus HB27”. Proc. Natl. Acad. Sci. USA 77: 1922-1926. PMID 6990416.
- ↑ Hori, H., Yamazaki, N., Matsumoto, T., Watanabe, Y., Ueda, T., Nishikawa, K., Kumagai, I. and Watanabe, K. (1998). „Substrate recognition of tRNA (guanosine-2′-)-methyltransferase from Thermus thermophilus HB27”. J. Biol. Chem. 273: 25721-25727. PMID 9748240.
- ↑ Pleshe, E., Truesdell, J. and Batey, R.T. (2005). „Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 722-728. PMID 16511140.
- ↑ Ochi, A., Makabe, K., Kuwajima, K. and Hori, H. (2010). „Flexible recognition of the tRNA G18 methylation target site by TrmH methyltransferase through first binding and induced fit processes”. J. Biol. Chem. 285: 9018-9029. PMID 20053984.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.