TRNK pseudouridinska55 sintaza
(Preusmjereno sa stranice TRNA:pseudouridine-55 synthase)
| TRNK pseudouridinska55 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.25 | ||||||||
| CAS broj | 430429-15-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK pseudouridinska55 sintaza (EC 5.4.99.25, TruB, aCbf5, Pus4, YNL292w (gen), Psi55 tRNK pseudouridin sintaza, tRNK:Psi55-sintaza, tRNK pseudouridin 55 sintaza, tRNK:pseudouridin-55 sintaza, Psi55 sintaza, tRNK Psi55 sintaza, tRNK:Psi55 sintaza, tRNK-uridin55 uracil mutaza, Pus10, tRNK-uridin54/55 uracil mutaza) je enzim sa sistematskim imenom tRNK-uridin55 uracil mutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNK uridin55 tRNK pseudouridin55
Pseudouridinska sintaza TruB iz Escherichia coli specifično modifikuje [uridin]]55 u tRNK molekulima.
Reference[uredi | uredi kod]
- ↑ Nurse, K., Wrzesinski, J., Bakin, A., Lane, B.G. and Ofengand, J. (1995). „Purification, cloning, and properties of the tRNA Ψ55 synthase from Escherichia coli”. RNA 1: 102-112. PMID 7489483.
- ↑ Becker, H.F., Motorin, Y., Planta, R.J. and Grosjean, H. (1997). „The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of Ψ55 in both mitochondrial and cytoplasmic tRNAs”. Nucleic Acids Res. 25: 4493-4499. PMID 9358157.
- ↑ Pienkowska, J., Wrzesinski, J. and Szweykowska-Kulinska, Z. (1998). „A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases”. Acta Biochim. Pol. 45: 745-754. PMID 9918501.
- ↑ Chaudhuri, B.N., Chan, S., Perry, L.J. and Yeates, T.O. (2004). „Crystal structure of the apo forms of Ψ55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft”. J. Biol. Chem. 279: 24585-24591. PMID 15028724.
- ↑ Hoang, C., Hamilton, C.S., Mueller, E.G. and Ferre-D'Amare, A.R. (2005). „Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain”. Protein Sci. 14: 2201-2206. PMID 15987897.
- ↑ Gurha, P. and Gupta, R. (2008). „Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA”. RNA 14: 2521-2527. PMID 18952823.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.