Sve-trans-retinil estar 13-cis izomerohidrolaza
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| Sve-trans-retinil estar 13-cis izomerohidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.90 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sve-trans-retinil estar 13-cis izomerohidrolaza (EC 3.1.1.90, All-trans-retinyl ester 13-cis isomerohydrolase) je enzim sa sistematskim imenom sve-trans-retinil estar acilhidrolaza, formira 13-cis retinol.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sve-trans-retinil estar + H2O 13-cis-retinol + masna kiselina
Sve-trans-retinilni estri, koji su oblik u kome se skladišti vitamin A, se formiraju posredstvom enzima EC 2.3.1.135, fosfatidilholin—retinol O-aciltransferaze (LRAT). Oni se mogu hidrolizovati do 11-cis-retinola posredstvom enzim EC 3.1.1.64, retinoid izomerohidrolaze (RPE65), ili do 13-cis-retinola destvom ovog enzima.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.