Sklareolna ciklaza
(Preusmjereno sa stranice Sklareol ciklaza)
| Sklareolna ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.7.4 | ||||||||
| CAS broj | 146838-18-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sklareolna ciklaza (EC 3.1.7.4, geranilgeranil pirofosfat:sklareol ciklaza, geranilgeranil pirofosfat-sklareol ciklaza, GGPP:sklareol ciklaza) je enzim sa sistematskim imenom geranilgeranil-difosfat difosfohidrolaza (formira sklareol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan jon Mg2+ ili Mn2+.
Reference[uredi | uredi kod]
- ↑ Banthorpe, D.V., Brown, J.T. and Morris, G.S. (1992). „Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material”. Phytochemistry 31: 3391-3395.
- ↑ Dimas, K., Hatziantoniou, S., Tseleni, S., Khan, H., Georgopoulos, A., Alevizopoulos, K., Wyche, J.H., Pantazis, P. and Demetzos, C. (2007). „Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice”. Apoptosis 12: 685-694. PMID 17260186.
- ↑ Guo, Z. and Wagner, G.J. (1995). „Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa”. Planta 197: 627-632.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.