Sfingomijelinska deacilaza

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Sfingomijelinska deacilaza
Identifikatori
EC broj 3.5.1.109
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Sfingomijelinska deacilaza (EC 3.5.1.109, SM deacilaza, GcSM deacilaza, glukozilkeramid sfingomijelinska deacilaza, sfingomijelin glukozilkeramidna deacilaza, SM glukozilkeramid GCer deacilaza, SM-GCer deacilaza, SMGCer deacilaza) je enzim sa sistematskim imenom N-acil-sfingozilfosforilholin amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) N-acil-sfingozilfosforilholin + H2O masna kiselina + sfingozilfosforilholin;;
(2) D-glukozil-N-acilsfingozin + H2O masna kiselina + D-glukozil-sfingozin

Ovaj enzim učestvuje u sfingolipidnom metabolizmu u epidermisu.

Reference[uredi - уреди | uredi izvor]

  1. Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". J. Invest. Dermatol. 115: 406–413. PMID 10951276. 
  2. Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". Biochem. J. 350: 747–756. PMID 10970788. 
  3. Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Lab. Invest. 83: 397–408. PMID 12649340. 

Literatura[uredi - уреди | uredi izvor]

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