Sferoiden monooksigenaza
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| Sferoiden monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.15.9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sferoiden monooksigenaza (EC 1.14.15.9, CrtA, aciklična karotenoidna 2-ketolaza, spiriloksantinska monooksigenaza, 2-okso-spiriloksantinska monooksigenaza) je enzim sa sistematskim imenom sferoiden,redukovani-feredoksin:kiseonik oksidoreduktaza (formira sferoiden-2-on).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sferoiden + redukovani feredoksin + O2 sferoiden-2-on + oksidovani feredoksin + H2O
- spiriloksantin + redukovani feredoksin + O2 2-oksospiriloksantin + oksidovani feredoksin + H2O
- 2'-oksospiriloksantin + redukovani feredoksin + O2 2,2'-dioksospiriloksantin + oksidovani feredoksin + H2O
Ovaj enzim učestvuje u biosintezi sferoidenona i 2,2'-dioksospiriloksantina. Enzim iz Rhodobacter sphaeroides sadrži heme u svom aktivnom mestu.
Reference[uredi | uredi kod]
- ↑ Lee, P.C., Holtzapple, E. and Schmidt-Dannert, C. (2010). „Novel activity of Rhodobacter sphaeroides spheroidene monooxygenase CrtA expressed in Escherichia coli”. Appl. Environ. Microbiol. 76: 7328-7331. PMID 20851979.
- ↑ Gerjets, T., Steiger, S. and Sandmann, G. (2009). „Catalytic properties of the expressed acyclic carotenoid 2-ketolases from Rhodobacter capsulatus and Rubrivivax gelatinosus”. Biochim. Biophys. Acta 1791: 125-131. PMID 19136077.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.