Sepiapterin reduktaza
(Preusmjereno sa stranice Sepijapterin reduktaza)
| Sepiapterin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Sepiapterin reduktaza homodimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.153 | ||||||||
| CAS broj | 9059-48-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sepiapterin reduktaza (EC 1.1.1.153, sepiapterinska reduktaza) je enzim sa sistematskim imenom L-eritro-7,8-dihidrobiopterin:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-eritro-7,8-dihidrobiopterin + NADP+ sepiapterin + NADPH + H+
- L-eritro-tetrahidrobiopterin + 2 NADP+ 6-piruvoil-5,6,7,8-tetrahidropterin + 2 NADPH + 2 H+
Ovaj enzim katalizuje finalni korak de novo sinteze tetrahidrobiopterina iz GTP-a. Enzim koji je prisutan kod viših životinja i nekih gljiva i bakterija, proizvodi eritro formu tetrahidrobiopterina, cf. EC 1.1.1.325, sepiapterin reduktaza (formira L-treo-7,8-dihidrobiopterin).
Reference[uredi | uredi kod]
- ↑ Katoh, S. (1971). „Sepiapterin reductase from horse liver: purification and properties of the enzyme”. Arch. Biochem. Biophys. 146: 202-214. PMID 4401291.
- ↑ Matsubara, M., Katoh, S., Akino, M. and Kaufman, S. (1966). „Sepiapterin reductase”. Biochim. Biophys. Acta 122: 202-212. PMID 5969298.
- ↑ Werner, E.R., Schmid, M., Werner-Felmayer, G., Mayer, B. and Wachter, H. (1994). „Synthesis and characterization of 3H-labelled tetrahydrobiopterin”. Biochem. J. 304: 189-193. PMID 7528005.
- ↑ Kim, Y.A., Chung, H.J., Kim, Y.J., Choi, Y.K., Hwang, Y.K., Lee, S.W. and Park, Y.S. (2000). „Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli”. Mol. Cells 10: 405-410. PMID 10987137.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.