2-Sukcinil-6-hidroksi-2,4-cikloheksadien-1-karboksilatna sintaza
(Preusmjereno sa stranice SHCHC synthase)
| 2-Sukcinil-6-hidroksi-2,4-cikloheksadien-1-karboksilatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.99.20 | ||||||||
| CAS broj | 122007-88-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Sukcinil-6-hidroksi-2,4-cikloheksadien-1-karboksilatna sintaza (EC 4.2.99.20, 2-sukcinil-6-hidroksi-2,4-cikloheksadien-1-karboksilna kiselina sintaza, 6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilatna sintaza, SHCHC sintaza, MenH, YfbB) je enzim sa sistematskim imenom 5-enolpiruvoil-6-hidroksi-2-sukcinilcikloheks-3-en-1-karboksilat piruvat-lijaza (formira (1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-enolpiruvoil-6-hidroksi-2-sukcinilcikloheks-3-en-1-karboksilat (1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat + piruvat
Ovaj enzim učestvuje u biosintezi vitamina K2 (menahinona).
- ↑ Jiang, M., Chen, X., Guo, Z.F., Cao, Y., Chen, M. and Guo, Z. (2008). „Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli”. Biochemistry 47: 3426-3434. PMID 18284213.
- ↑ Jiang, M., Cao, Y., Guo, Z.F., Chen, M., Chen, X. and Guo, Z. (2007). „Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity”. Biochemistry 46: 10979-10989. PMID 17760421.
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