Arsenit metiltransferaza
(Preusmjereno sa stranice S-adenozil-L-metionin:arsenite As-methyltransferase)
Arsenit metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.137 | ||||||||
CAS broj | 167140-41-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Arsenit metiltransferaza (EC 2.1.1.137, S-adenozil-L-metionin:arsenik(III) metiltransferaza, S-adenozil-L-metionin:metilarsonit As-metiltransferaza, metilarsonit metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:arsenit As-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) S-adenozil-L-metionin + arsenit S-adenozil-L-homocistein + metilarsonat
- (2) S-adenozil-L-metionin + metilarsonit S-adenozil-L-homocistein + dimetilarsinat
Ova enzim učestvuje u biotransformacionom putu kojim se formira dimetilarsinat iz nerganskih arsenita i arsenata.
- ↑ Zakharyan, R.A. and Aposhian, H.V. (1999). „Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase”. Chem. Res. Toxicol. 12: 1278-1283. PMID 10604879.
- ↑ Zakharyan, R.A., Ayala-Fierro, F., Cullen, W.R., Carter, D.M. and Aposhian, H.V. (1999). „Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes”. Toxicol. Appl. Pharmacol. 158: 9-15. PMID 10387927.
- ↑ Zakharyan, R.A., Wildfang, E. and Aposhian, H.V. (1996). „Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic”. Toxicol. Appl. Pharmacol. 140: 77-84. PMID 8806872.
- ↑ Zakharyan, R.A., Wu, Y., Bogdan, G.M. and Aposhian, H.V. (1995). „Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver”. Chem. Res. Toxicol. 8: 1029-1038. PMID 8605285.
- ↑ Lin, S., Shi, Q., Nix, F.B., Styblo, M., Beck, M.A., Herbin-Davis, K.M., Hall, L.L., Simeonsson, J.B. and Thomas, D.J. (2002). „A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol”. J. Biol. Chem. 277: 10795-10803. PMID 11790780.
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