Adenozilhomocisteinska nukleozidaza
(Preusmjereno sa stranice S-adenozil-L-homocisteinska homocisteinilribohidrolaza)
| Adenozilhomocisteinska nukleozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.9 | ||||||||
| CAS broj | 2613585 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Adenozilhomocisteinska nukleozidaza (EC 3.2.2.9, S-adenozilhomocisteinska hidrolaza, S-adenozilhomocisteinska nukleozidaza, 5'-metiladenozinska nukleozidaza, S-adenozilhomocistein/5'-metiltioadenozin nukleozidaza, AdoHcy/MTA nukleozidaza) je enzim sa sistematskim imenom S-adenozil-L-homocisteinska homocisteinilribohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-homocistein + H2O S-(5-dezoksi-D-ribos-5-il)-L-homocistein + adenin
Ovaj enzim takođe deluje na S-metil-5'-tioadenozin, čime se formira adenin i S-metil-5-tioriboza (cf. EC 3.2.2.16, metiltioadenozin nukleozidaza).
Reference[uredi | uredi kod]
- ↑ Duerre, J.A. (1962). „A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine”. J. Biol. Chem. 237: 3737-3741.
- ↑ Ferro, A.J., Barrett, A. and Shapiro, S.K. (1976). „Kinetic properties and the effect of substrate analogues on 5′-methylthioadenosine nucleosidase from Escherichia coli”. Biochim. Biophys. Acta 438: 487-494. PMID 782530.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.