S-(hidroksimetil)mikotiol dehidrogenaza
(Preusmjereno sa stranice S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase)
| S-(hidroksimetil)mikotiol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.306 | ||||||||
| CAS broj | 192140-85-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
S-(hidroksimetil)mikotiol dehidrogenaza (EC 1.1.1.306, NAD/factor-zavisna formaldehidna dehidrogenaza, mikotiol-zavisna formaldehidna dehidrogenaza) je enzim sa sistematskim imenom S-(hidroksimetil)mikotiol:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-(hidroksimetil)mikotiol + NAD+ S-formilmikotiol + NADH + H+
Smatra se da se S-hidroksimetilmikotiol spontano formira iz formaldehida i mikotiola. Ovaj enzim oksiduje produkt te spontane reakcije do S-formilmikotiola, u reakciji koja je analogna sa dejstvom EC 1.1.1.284, S-(hidroksimetil)glutation dehidrogenaze.
Reference[uredi | uredi kod]
- ↑ Misset-Smits, M., Van Ophem, P.W., Sakuda, S. and Duine, J.A. (1997). „Mycothiol, 1-O-(2′-[N-acetyl-L-cysteinyl]amido-2′-deoxy-α-D-glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase”. FEBS Lett. 409: 221-222. PMID 9202149.
- ↑ Norin, A., Van Ophem, P.W., Piersma, S.R., Person, B., Duine, J.A. and Jornvall, H. (1997). „Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaryotic alcohol dehydrogenase's - primary structure, conformational modelling and functional correlations”. Eur. J. Biochem. 248: 282-289. PMID 9346279.
- ↑ Vogt, R.N., Steenkamp, D.J., Zheng, R. and Blanchard, J.S. (2003). „The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase”. Biochem. J. 374: 657-666. PMID 12809551.
- ↑ Rawat, M. and Av-Gay, Y. (2007). „Mycothiol-dependent proteins in actinomycetes”. FEMS Microbiol. Rev. 31: 278-292. PMID 17286835.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.