Ribonukleaza D
Prijeđi na navigaciju
Prijeđi na pretragu
| Ribonukleaza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.13.5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ribonukleaza D (EC 3.1.13.5, RNaza D) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eksonukleolitičko razlaganje kojim se uklanjaju ekstra ostataci sa 3'-terminusa tRNK i formiraju 5'-mononukleotidi
Za rad ovog enzima su neophodni dvovalentni katjoni (Mg2+, Mn2+ ili Co2+).
Reference[uredi | uredi kod]
- ↑ Ghosh, R.K. and Deutscher, M.P. (1978). „Identification of an Escherichia coli nuclease acting on structurally altered transfer RNA molecules”. J. Biol. Chem. 253: 997-1000. PMID 342522.
- ↑ Cudny, H., Zaniewski, R. and Deutscher, M.P. (1981). „Escherichia coli RNase D. Purification and structural characterization of a putative processing nuclease”. J. Biol. Chem. 256: 5627-5632. PMID 6263885.
- ↑ Cudny, H., Zaniewski, R. and Deutscher, M.P. (1981). „Escherichia coli RNase D. Catalytic properties and substrate specificity”. J. Biol. Chem. 256: 5633-5637. PMID 6263886.
- ↑ Zhang, J.R. and Deutscher, M.P. (1988). „Cloning, characterization, and effects of overexpression of the Escherichia coli rnd gene encoding RNase D”. J. Bacteriol. 170: 522-527. PMID 2828310.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.