N-acetilgalaktozamin-N,N'-diacetilbacillosaminil-difosfo-undekaprenol 4-alfa-N-acetilgalaktozaminiltransferaza
(Preusmjereno sa stranice PglJ)
| N-acetilgalaktozamin-N,N'-diacetilbacillosaminil-difosfo-undekaprenol 4-alfa-N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.291 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acetilgalaktozamin-N,N'-diacetilbacillosaminil-difosfo-undekaprenol 4-alfa-N-acetilgalaktozaminiltransferaza (EC 2.4.1.291, PglJ) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-galaktozamin:N-acetilgalaktozaminil-alfa-(1->3)-N,N'-diacetil-alfa-D-bacilozaminil-difosfo-tritrans,heptacis-undekaprenol 3-alfa-N-acetil-D-galaktozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-galaktozamin + N-acetil-D-galaktozaminil-alfa-(1->3)-N,N'-diacetil-alfa-D-bacillosaminil-difosfo-tritrans,heptacis-undekaprenol UDP + N-acetil-D-galaktozaminil-alfa-(1->4)-N-acetil-D-galaktozaminil-alfa-(1->3)-N,N'-diacetil-alfa-D-bacillosaminil-difosfo-tritrans,heptacis-undekaprenol
Ovaj enzim je izolovan iz Campylobacter jejuni.
Reference[uredi | uredi kod]
- ↑ Glover, K.J., Weerapana, E. and Imperiali, B. (2005). „In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation”. Proc. Natl. Acad. Sci. USA 102: 14255-14259. PMID 16186480.
- ↑ Chen, M.M., Weerapana, E., Ciepichal, E., Stupak, J., Reid, C.W., Swiezewska, E. and Imperiali, B. (2007). „Polyisoprenol specificity in the Campylobacter jejuni N-linked glycosylation pathway”. Biochemistry 46: 14342-14348. PMID 18034500.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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