Peptidilna dipeptidaza B
(Preusmjereno sa stranice Peptidil-dipeptidaza B)
| Peptidilna dipeptidaza B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.15.4 | ||||||||
| CAS broj | 147014-93-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Peptidilna dipeptidaza B (EC 3.4.15.4, dipeptidilna karboksihidrolaza, atriopeptinska konvertaza, atrijalna di-(tri)peptidilna karboksihidrolaza, peptidilnadipeptidaza B, atrijalna dipeptidilna karboksihidrolaza, atrijalna peptidna konvertaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalnog dipeptida ili u retkim slučajevima tripeptida
Ova membranska, cinkova metalopeptidaza je prisutan u sisarskim atrijalnim miocitima.
Reference[uredi | uredi kod]
- ↑ Harris, R.B. and Wilson, I.B. (1984). „Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization”. Arch. Biochem. Biophys. 233: 667-675. PMID 6385859.
- ↑ Harris, R.B. and Wilson, I.B. (1985). „Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase”. Peptides (Fayetteville) 6: 393-396. PMID 2999723.
- ↑ Soler, D.F. and Harris, R.B. (1988). „Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position”. Int. J. Peptide Protein Res. 32: 35-40. PMID 3146555.
- ↑ Soler, D.F. and Harris, R.B. (1989). „Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity”. Peptides (Fayetteville) 10: 63-68. PMID 2501770.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.