Pepsin-A

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa Pepsin)
Pepsin-A
1pso.jpg
Pepsin, Human
Identifikatori
EC broj 3.4.23.1
CAS broj 9001-75-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pepsin-A (EC 3.4.23.1, pepsin, laktatedni pepsin, pepsinski fortior, fundus-pepsin, eliksir laktatnog pepsina, P I, laktatedno pepsinski eliksir, P II, pepsin R, pepsin D) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaganje: hidrofobnih, preferentno aromatičnih, ostataka u P1 i P1' pozicijama. Razlaganje Phe1-Val, Gln4-His, Glu13-Ala, Ala14-Leu, Leu15-Tyr, Tyr16-Leu, Gly23-Phe, Phe24-Phe i Phe25-Tyr veza u B lancima insulina

Ovaj enzim je predominantna endopeptidaza u gastričnom soku kičmenjaka.

Reference[uredi - уреди | uredi izvor]

  1. Lee, D. and Ryle, A.P. (1967). "Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa". Biochem. J. 104: 735–741. PMID 4167464. 
  2. Lee, D. and Ryle, A.P. (1967). "Pepsin D. A minor component of commercial pepsin preparations". Biochem. J. 104: 742–748. PMID 4860638. 
  3. Foltmann, R. (1981). "Gastric proteinases -structure, function, evolution and mechanism of action". Essays Biochem. 17: 52–84. PMID 6795036. 
  4. James, M.N.G. and Sielecki, A.R. (1986). "Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 Å resolution". Nature 319: 33–38. PMID 3941737. 
  5. Fruton, J.S. (1987). "Aspartyl proteinases". u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. 16. Amsterdam: Elsevier. str. 1-38. 
  6. Tang, J. and Wong, R.N.S. (1987). "Evolution in the structure and function of aspartic proteases". J. Cell. Biochem. 33: 53–63. PMID 3546346. 
  7. Pohl, J. and Dunn, B.M. (1988). "Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site". Biochemistry 27: 4827–4834. PMID 3139029. 

Literatura[uredi - уреди | uredi izvor]

  • Fruton, J.S. (1987). "Aspartyl proteinases". u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. 16. Amsterdam: Elsevier. str. 1-38. 

Spoljašnje veze[uredi - уреди | uredi izvor]