PRE-084

PRE-084
(IUPAC) ime
	2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
Klinički podaci
Identifikatori
CAS broj	138847-85-5
ATC kod	nije dodeljen
PubChem	126402
Hemijski podaci
Formula	C19H27NO3
Mol. masa	317.422 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2 ; Key: RQHKZUBCUZVZEF-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

PRE-084 je agonist sigma receptor, koji je selektivan za σ₁ tip. On je pokazao nootropno i antidepresivno dejstvo u studijama na životinjama, da može da služi kao sredstvo protiv kašlja.^[3]^[4]^[5]^[6]^[7] PRE-084 povišava GDNF izražavanje.^[8]

Literatura[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994). „PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice”. Pharmacology, Biochemistry, and Behavior 49 (4): 859–69. PMID 7886099.
↑ Maurice T (November 2001). „Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats”. European Journal of Pharmacology 431 (2): 223–7. PMID 11728429.
↑ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004). „Antitussive activity of sigma-1 receptor agonists in the guinea-pig”. British Journal of Pharmacology 141 (2): 233–40. DOI:10.1038/sj.bjp.0705605. PMC 1574192. PMID 14691051.
↑ Skuza G, Rogóz Z (2009). „Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice”. Pharmacological Reports : PR 61 (6): 1179–83. PMID 20081254.
↑ Hiranita T, Soto PL, Tanda G, Katz JL (February 2010). „Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine”. The Journal of Pharmacology and Experimental Therapeutics 332 (2): 515–24. DOI:10.1124/jpet.109.159236. PMID 19892920.
↑ PMID 21332255

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid7886099-3] Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994). „PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice”. Pharmacology, Biochemistry, and Behavior 49 (4): 859–69. PMID 7886099.

[pmid11728429-4] Maurice T (November 2001). „Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats”. European Journal of Pharmacology 431 (2): 223–7. PMID 11728429.

[pmid14691051-5] Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004). „Antitussive activity of sigma-1 receptor agonists in the guinea-pig”. British Journal of Pharmacology 141 (2): 233–40. DOI:10.1038/sj.bjp.0705605. PMC 1574192. PMID 14691051.

[pmid20081254-6] Skuza G, Rogóz Z (2009). „Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice”. Pharmacological Reports : PR 61 (6): 1179–83. PMID 20081254.

[pmid19892920-7] Hiranita T, Soto PL, Tanda G, Katz JL (February 2010). „Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine”. The Journal of Pharmacology and Experimental Therapeutics 332 (2): 515–24. DOI:10.1124/jpet.109.159236. PMID 19892920.

[8] PMID 21332255

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PRE-084

Literatura[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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