Nelfinavir

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Nelfinavir
(IUPAC) ime
(3S,4aS,8aS)-N-tert-butil-2-[(2R,3R)-2-hidroksi-3-[(3-hidroksi-2-metilfenil)formamido]-4-(fenilsulfanil)butil]-dekahidroizohinolin-3-karboksamid
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 159989-64-7
ATC kod J05AE04
PubChem[1][2] 64143
DrugBank DB00220
ChemSpider[3] 57718
KEGG[4] C07257 YesY
Hemijski podaci
Formula C32H45N3O4S 
Mol. masa 567.782
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 349.84 °C (662 °F)
Farmakokinetički podaci
Poluvreme eliminacije 3,5 - 5 sata
Izlučivanje 87% fekalno
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status
Način primene Oralno

Nelfinavir je potent inhibitor HIV-1 proteaze. On se koristi u kombinaciji sa drugim antiviralnim lekovima u tretmanu HIV-a kod odraslih i dece.[5][6][7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH: Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85. PMID 9397180
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  7. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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