NADH:ubihinon reduktaza (Na+-transport)
(Preusmjereno sa stranice Na+-translocirajući NADH-hinon reduktaza)
| NADH:ubihinon reduktaza (Na+-transport) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.6.5.8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
NADH:ubihinon reduktaza (Na+-transport) (EC 1.6.5.8, Na+-translocirajući NADH-hinon reduktaza, (Na+-NQR)) je enzim sa sistematskim imenom NADH:ubihinon oksidoreduktaza (Na+-translocating).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj flavoprotein sadrži dva kovalentno vezana FMN molekula, jedan nekovalentno vezan FAD, jedan riboflavin, i jedan [2Fe-2S] klaster.
Reference[uredi | uredi kod]
- ↑ Beattie, P., Tan, K., Bourne, R.M., Leach, D., Rich, P.R. and Ward, F.B. (1994). „Cloning and sequencing of four structural genes for the Na+-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus”. FEBS Lett. 356: 333-338. PMID 7805867.
- ↑ Nakayama, Y., Hayashi, M. and Unemoto, T. (1998). „Identification of six subunits constituting Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus”. FEBS Lett. 422: 240-242. PMID 9490015.
- ↑ Bogachev, A.V., Bertsova, Y.V., Barquera, B. and Verkhovsky, M.I. (2001). „Sodium-dependent steps in the redox reactions of the Na+-motive NADH:quinone oxidoreductase from Vibrio harveyi”. Biochemistry 40: 7318-7323. PMID 11401580.
- ↑ Barquera, B., Hellwig, P., Zhou, W., Morgan, J.E., Hase, C.C., Gosink, K.K., Nilges, M., Bruesehoff, P.J., Roth, A., Lancaster, C.R. and Gennis, R.B. (2002). „Purification and characterization of the recombinant Na+-translocating NADH:quinone oxidoreductase from Vibrio cholerae”. Biochemistry 41: 3781-3789. PMID 11888296.
- ↑ Barquera, B., Nilges, M.J., Morgan, J.E., Ramirez-Silva, L., Zhou, W. and Gennis, R.B. (2004). „Mutagenesis study of the 2Fe-2S center and the FAD binding site of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae”. Biochemistry 43: 12322-12330. PMID 15379571.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.