Diadenozin heksafosfatna hidrolaza (formira AMP)
(Preusmjereno sa stranice NUDT10 (gene name))
| Diadenozin heksafosfatna hidrolaza (formira AMP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.60 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diadenozin heksafosfatna hidrolaza (formira AMP) (EC 3.6.1.60, hAps1, NUDT11 (gen), hAps2, NUDT10 (gen)) je enzim sa sistematskim imenom P1,P6-bis(5'-adenozil)heksafosfat nukleotidohidrolaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) P1,P6-bis(5'-adenozil)heksafosfat + H2O adenozin 5'-pentafosfat + AMP
- (2) P1,P5-bis(5'-adenozil)pentafosfat + H2O adenozin 5'-tetrafosfat + AMP
Dvovalentni kation je esencijalan za aktivnost.
Reference[uredi | uredi kod]
- ↑ Leslie, N.R., McLennan, A.G. and Safrany, S.T. (2002). „Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases”. BMC Biochem 3: #20-20. PMID 12121577.
- ↑ Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D. and Shears, S.B. (1999). „The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein”. J. Biol. Chem. 274: 21735-21740. PMID 10419486.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.