N-hidroksi-2-acetamidofluor reduktaza
(Preusmjereno sa stranice NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase)
| N-hidroksi-2-acetamidofluor reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.1.12 | ||||||||
| CAS broj | 99890-08-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-hidroksi-2-acetamidofluor reduktaza (EC 1.7.1.12, N-hidroksi-2-acetilaminofluorna reduktaza, NAD(P)H:N-hidroksi-2-acetamidofluorna N-oksidoreduktaza) je enzim sa sistematskim imenom 2-acetamidofluor:NAD(P)+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-acetamidofluor + NAD(P)+ + H2O N-hidroksi-2-acetamidofluor + NAD(P)H + H+
Ovaj enzim takođe deluje, mada sporo, na N-hidroksi-4-acetamidobifenil.
Reference[uredi | uredi kod]
- ↑ Gutmann, H.R. and Erickson, R.R. (1969). „The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction”. J. Biol. Chem. 244: 1729-1740. PMID 5780838.
- ↑ Kitamura, S. and Tatsumi, K. (1985). „Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol”. Biochem. Biophys. Res. Commun. 133: 67-74. PMID 4074379.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.