NAD+ nukleozidaza
(Preusmjereno sa stranice NAD+ nucleosidase)
| NAD+ nukleozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.5 | ||||||||
| CAS broj | 9032-65-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
NAD+ nukleozidaza (EC 3.2.2.5, NADaza, DPNaza, DPN hidrolaza, NAD hidrolaza, difosfopiridinska nukleozidaza, nikotinamid adenin dinukleotidna nukleozidaza, NAD glikohidrolaza, NAD nukleozidaza, nikotinamid adenin dinukleotidna glikohidrolaza) je enzim sa sistematskim imenom NAD+ glikohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- NAD+ + H2O ADP-riboza + nikotinamid
Ovaj enzim takođe može u manjoj meri da hidrolizuje NADP+ čime se formira fosfo-ADP-riboza i nikotinamid.
Reference[uredi | uredi kod]
- ↑ Hofmann, E.C.G. and Rapoport, S. (1955). „DPN- und TPN-spezifische Nukleosidasen in Erythrozyten”. Biochim. Biophys. Acta 18: 296-296. PMID 13276383.
- ↑ Nakazawa, K., Ueda, K., Honjo, T., Yoshihara, K., Nishizuka, Y. and Hayaishi, O. (1968). „Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver”. Biochem. Biophys. Res. Commun. 32: 143-149. PMID 5672131.
- ↑ Ueda, K., Fukushima, M., Okayamo, H. and Hayaishi, O. (1975). „Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme”. J. Biol. Chem. 250: 7541-7546. PMID 240831.
- ↑ Yamamoto-Katayama, S., Ariyoshi, M., Ishihara, K., Hirano, T., Jingami, H. and Morikawa, K. (2002). „Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities”. J. Mol. Biol. 316: 711-723. PMID 11866528.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.