N-sulfoglukozaminska 3-sulfataza
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| N-sulfoglukozaminska 3-sulfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.6.15 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-sulfoglukozaminska 3-sulfataza (EC 3.1.6.15, hondroitinsulfataza) je enzim sa sistematskim imenom N-sulfo-3-sulfoglukozamin 3-sulfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza 3-sulfatnih grupa N-sulfo-D-glukozamin 3-O-sulfatnih jedinica heparina
Enzim iz Flavobacterium heparinum takođe hidrolizuje N-acetil-D-glukozamin 3-O-sulfat.
Reference[uredi | uredi kod]
- ↑ Bruce, J.S., McLean, M.W., Long, W.F. and Williamson, F.B. (1985). „Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate”. Eur. J. Biochem. 148: 359-365. PMID 3987694.
- ↑ Leder, I.G. (1980). „A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-α-D-glucopyranoside 3-sulfate”. Biochem. Biophys. Res. Commun. 94: 1183-1189. PMID 7396957.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.