N-sukcinilargininska dihidrolaza
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| N-sukcinilargininska dihidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.3.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-sukcinilargininska dihidrolaza (EC 3.5.3.23, N2-sukcinilargininska dihidrolaza, argininska sukcinilhidrolaza, SADH, AruB, AstB, 2-N-sukcinil-L-arginin iminohidrolaza (dekarboksilacija)) je enzim sa sistematskim imenom N2-sukcinil-L-arginin iminohidrolaza (dekarboksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N2-sukcinil-L-arginin + 2H2O N2-sukcinil-L-ornitin + 2 NH3 + CO2
Arginin, N2-acetilarginin i N2-glutamilarginin nisu supstrati.
Reference[uredi | uredi kod]
- ↑ Schneider, B.L., Kiupakis, A.K. and Reitzer, L.J. (1998). „Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli”. J. Bacteriol. 180: 4278-4286. PMID 9696779.
- ↑ Tocilj, A., Schrag, J.D., Li, Y., Schneider, B.L., Reitzer, L., Matte, A. and Cygler, M. (2005). „Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli”. J. Biol. Chem. 280: 15800-15808. PMID 15703173.
- ↑ Vander Wauven, C. and Stalon, V. (1985). „Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia”. J. Bacteriol. 164: 882-886. PMID 2865249.
- ↑ Cunin, R., Glansdorff, N., Pierard, A. and Stalon, V. (1986). „Biosynthesis and metabolism of arginine in bacteria”. Microbiol. Rev. 50: 314-352. PMID 3534538.
- ↑ Itoh, Y. (1997). „Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa”. J. Bacteriol. 179: 7280-7290. PMID 9393691.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.