Monociklični monoterpen keton monooksigenaza
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| Monociklični monoterpen keton monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.105 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Monociklični monoterpen keton monooksigenaza (EC 1.14.13.105, 1-hidroksi-2-oksolimonen 1,2-monooksigenaza, dihidrokarvonska 1,2-monooksigenaza, MMKMO) je enzim sa sistematskim imenom (-)-menton,NADPH:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) (-)-menton + NADPH + H+ + O2 (4R,7S)-7-izopropil-4-metiloksepan-2-on + NADP+ + H2O
- (2) dihidrokarvon + NADPH + H+ + O2 4-izopropenil--7-metiloksepan-2-on + NADP+ + H2O
- (3) (izo)-dihidrokarvon + NADPH + H+ + O2 6-izopropenil--3-metiloksepan-2-on + NADP+ + H2O
- (4a) 1-hidroksimenth-8-en-2-on + NADPH + H+ + O2 7-hidroksi-4-izopropenil--7-metiloksepan-2-on + NADP+ + H2O
- (4b) 7-hidroksi-4-izopropenil--7-metiloksepan-2-on 3-izopropenil--6-oksoheptanoat (spontana reakcija)
Ovaj enzim je flavoprotein (FAD).
Reference[uredi | uredi kod]
- ↑ van der Werf, M.J., Swarts, H.J. and de Bont, J.A. (1999). „Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene”. Appl. Environ. Microbiol. 65: 2092-2102. PMID 10224006.
- ↑ Van Der Werf, M.J. (2000). „Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways”. Biochem. J. 347: 693-701. PMID 10769172.
- ↑ van der Werf, M.J. and Boot, A.M. (2000). „Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14”. Microbiology 146: 1129-1141. PMID 10832640.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.