UDP-N-acetilglukozaminska 2-epimeraza
(Preusmjereno sa stranice MnaA (gen))
| UDP-N-acetilglukozaminska 2-epimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 5.1.3.14 | ||||||||
| CAS broj | 9037-71-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-N-acetilglukozaminska 2-epimeraza (EC 5.1.3.14, UDP-N-acetilglukozamin 2'-epimeraza, uridin difosfoacetilglukozaminska 2'-epimeraza, uridin difosfo-N-acetilglukozaminska 2'-epimeraza, uridin difosfat-N-acetilglukozamin-2'-epimeraza, rffE (gen), mnaA (gen), UDP-N-acetil-D-glukozamin 2-epimeraza) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin 2-epimeraza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin UDP-N-acetil-alfa-D-manozamin
Ovaj bakterijski enzim katalizuje reverzibilnu interkonverziju UDP-GlcNAc i UDP-ManNAc.
- ↑ Kawamura, T., Kimura, M., Yamamori, S. and Ito, E. (1978). „Enzymatic formation of uridine diphosphate N-acetyl-D-mannosamine”. J. Biol. Chem. 253: 3595-3601. PMID 418068.
- ↑ Meier-Dieter, U., Starman, R., Barr, K., Mayer, H. and Rick, P.D. (1990). „Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis”. J. Biol. Chem. 265: 13490-13497. PMID 2166030.
- ↑ Morgan, P. M., Sala, R. F., and Tanner, M. E. (1997). „Eliminations in the reactions catalyzed by UDP-N-acetylglucosamine 2-epimerase”. J. Am. Chem. Soc. 119: 10269-10277.
- ↑ Campbell, R.E., Mosimann, S.C., Tanner, M.E. and Strynadka, N.C. (2000). „The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases”. Biochemistry 39: 14993-15001. PMID 11106477.
- ↑ Samuel, J. and Tanner, M.E. (2004). „Active site mutants of the "non-hydrolyzing" UDP-N-acetylglucosamine 2-epimerase from Escherichia coli”. Biochim. Biophys. Acta 1700: 85-91. PMID 15210128.
- ↑ Soldo, B., Lazarevic, V., Pooley, H.M. and Karamata, D. (2002). „Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase”. J. Bacteriol. 184: 4316-4320. PMID 12107153.
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