Malonil KoA reduktaza (formira malonat semialdehid)
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| Malonil KoA reduktaza (formira malonat semialdehid) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.75 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Malonil KoA reduktaza (formira malonat semialdehid) (EC 1.2.1.75, NADP-zavisni malonil KoA reduktaza, malonil KoA reduktaza (NADP)) je enzim sa sistematskim imenom malonat semialdehid:NADP+ oksidoreduktaza (formira malonat semialdehid).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- malonat semialdehid + KoA + NADP+ malonil-KoA + NADPH + H+
Za rad ovog enzima je neohodan Mg2+. On katalizuje redukciju malonil-KoA do malonat semialdehida, što je ključni korak u ciklusu 3-hidroksipropionata i 3-hidroksipropionat/4-hidroksibutirata, putevima autotrofne CO2 fiksacija prisutnim kod nekih zelenih nesumpornih fototrofnih bakterija i nekih termoacidofilnih arheja, respektivno. Enzim iz Sulfolobus tokodaii je prečišćen i utvrđeno je da sadrži jedan RNK molekul za dve podjedinice.
Reference[uredi | uredi kod]
- ↑ Strauss, G. and Fuchs, G. (1993). „Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle”. Eur. J. Biochem. 215: 633-643. PMID 8354269.
- ↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). „A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea”. Science 318: 1782-1786. PMID 18079405.
- ↑ Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., Hugler, M. and Fuchs, G. (2006). „Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp”. J. Bacteriol. 188: 8551-8559. PMID 17041055.
- ↑ Hugler, M., Menendez, C., Schagger, H. and Fuchs, G. (2002). „Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation”. J. Bacteriol. 184: 2404-2410. PMID 11948153.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.