Malonil-KoA O-metiltransferaza
| Malonil-KoA O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.197 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Malonil-KoA O-metiltransferaza (EC 2.1.1.197, BioC) je enzim sa sistematskim imenom S-adenozil-L-metionin:malonil-KoA O-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + malonil-KoA S-adenozil-L-homocistein + malonil-KoA metil estar
Ovaj enzim učestvuje u početnom delu biosinteze Gram-negativnih bakterija. On katalizuje transfer metil grupe na omega-karboksilnu grupu pri čemu se formira malonil-KoA metil estar. Taj estar prepoznaju enzimi sinteze masnih kiselina, koji produžavaju masne kiseline i formiraju pimelil-[acil-nosilac-protein] metil estar.
- ↑ Del Campillo-Campbell, A., Kayajanian, G., Campbell, A. and Adhya, S. (1967). „Biotin-requiring mutants of Escherichia coli K-12”. J. Bacteriol. 94: 2065-2066. PMID 4864413.
- ↑ Rolfe, B. and Eisenberg, M.A. (1968). „Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12”. J. Bacteriol. 96: 515-524. PMID 4877129.
- ↑ Otsuka, A.J., Buoncristiani, M.R., Howard, P.K., Flamm, J., Johnson, C., Yamamoto, R., Uchida, K., Cook, C., Ruppert, J. and Matsuzaki, J. (1988). „The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon”. J. Biol. Chem. 263: 19577-19585. PMID 3058702.
- ↑ Cleary, P.P. and Campbell, A. (1972). „Deletion and complementation analysis of biotin gene cluster of Escherichia coli”. J. Bacteriol. 112: 830-839. PMID 4563978.
- ↑ Lin, S., Hanson, R.E. and Cronan, J.E. (2010). „Biotin synthesis begins by hijacking the fatty acid synthetic pathway”. Nat. Chem. Biol.: -. PMID 20693992.
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