Kalikrein 8
(Preusmjereno sa stranice MK8)
Kalikrein 8 | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.21.118 | ||||||||
CAS broj | 171715-15-4 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kalikrein 8 (EC 3.4.21.118, KLK8, PRSS19, ljudski kalikrein 8, hK8, mK8, ovasin, tumor-asocirani diferenciono izraženi gen 14, TADG-14, NP, neuropsin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje amidnih supstrata koji slede bazne aminokiseline Arg ili Lys u P1 poziciji, sa preferencijom za Arg u odnosu na Lys
Ovaj enzim se aktivira odstranjivanjem N-terminalnog prepropeptida.
Reference[uredi | uredi kod]
- ↑ Chen, Z.L., Yoshida, S., Kato, K., Momota, Y., Suzuki, J., Tanaka, T., Ito, J., Nishino, H., Aimoto, S., Kiyama, H. and Shiosaka, S. (1995). „Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus”. J. Neurosci. 15: 5088-5097. PMID 7623137.
- ↑ Shimizu, C., Yoshida, S., Shibata, M., Kato, K., Momota, Y., Matsumoto, K., Shiosaka, T., Midorikawa, R., Kamachi, T., Kawabe, A. and Shiosaka, S. (1998). „Characterization of recombinant and brain neuropsin, a plasticity-related serine protease”. J. Biol. Chem. 273: 11189-11196. PMID 9556608.
- ↑ Rajapakse, S., Ogiwara, K., Takano, N., Moriyama, A. and Takahashi, T. (2005). „Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins”. FEBS Lett. 579: 6879-6884. PMID 16337200.
- ↑ Kishi, T., Cloutier, S.M., Kündig, C., Deperthes, D. and Diamandis, E.P. (2006). „Activation and enzymatic characterization of recombinant human kallikrein 8”. Biol. Chem. 387: 723-731. PMID 16800733.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.