Serinska proteaza-2
(Preusmjereno sa stranice MASP2)
| Serinska proteaza-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.104 | ||||||||
| CAS broj | 214915-16-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Serinska proteaza-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-asocirana serinska proteaza-2, manozno-vezujuća proteaza-2 asocirana sa lektinom, p100, manan-vezujuća lektin-asocirana serin peptidaza 2) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje iza Arg223 u komplementnoj komponenti C2 (-Ser-Leu-Gly-Arg-Lys-Ile-GlnIle) i iza Arg76 u komplementnoj komponenti C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)
Ovaj manan-vezujući lektin (MBL) prepoznaje obrsce neutralnih ugljenih hidrata.
Reference[uredi | uredi kod]
- ↑ Matsushita, M. and Fujita, T. (1992). „Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease”. J. Exp. Med. 176: 1497-1502. PMID 1460414.
- ↑ Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B. and Jensenius, J.C. (1997). „A second serine protease associated with mannan-binding lectin that activates complement”. Nature 386: 506-510. PMID 9087411.
- ↑ Rossi, V., Cseh, S., Bally, I., Thielens, N.M., Jensenius, J.C. and Arlaud, G.J. (2001). „Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2”. J. Biol. Chem. 276: 40880-40887. PMID 11527969.
- ↑ Ambrus, G., Gal, P., Kojima, M., Szilagyi, K., Balczer, J., Antal, J., Graf, L., Laich, A., Moffatt, B.E., Schwaeble, W., Sim, R.B. and Zavodszky, P. (2003). „Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments”. J. Immunol. 170: 1374-1382. PMID 12538697.
- ↑ Harmat, V., Gal, P., Kardos, J., Szilagyi, K., Ambrus, G., Vegh, B., Naray-Szabo, G. and Zavodszky, P. (2004). „The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions”. J. Mol. Biol. 342: 1533-1546. PMID 15364579.
- ↑ Chen, C.B. and Wallis, R. (2004). „Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases”. J. Biol. Chem. 279: 26058-26065. PMID 15060079.
- ↑ Teillet, F., Dublet, B., Andrieu, J.P., Gaboriaud, C., Arlaud, G.J. and Thielens, N.M. (2005). „The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases”. J. Immunol. 174: 2870-2877. PMID 15728497.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.