Ljudska endogena retrovirusna K endopeptidaza
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| Ljudska endogena retrovirusna K endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.50 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ljudska endogena retrovirusna K endopeptidaza (EC 3.4.23.50, ljudska endogena retrovirusna K10 endopeptidaza, endogena retrovirusna HERV-K10 proteaza, ljudki endogeni retrovirusni K retropepsin, HERV K10 endopeptidaza, HERV K10 retropepsin, HERV-K PR, HERV-K proteaza, HERV-K113 proteaza, ljuska endogena retrovirusna K113 proteaza, ljuski retrovirusni K10 retropepsin) je enzim.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Modifikacija autentičnog HIV-1 PR mesta prepoznavanja i oslobađanje maturisanih p17 matriks i p24 kapsidnih proteina, što je posledica presecanja -SQNY-PIVQ- motiva
Ovaj enzim pripada peptidaznoj familiji A2.
Reference[uredi | uredi kod]
- ↑ Towler, E.M., Gulnik, S.V., Bhat, T.N., Xie, D., Gustschina, E., Sumpter, T.R., Robertson, N., Jones, C., Sauter, M., Mueller-Lantzsch, N., Debouck, C. and Erickson, J.W. (1998). „Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease”. Biochemistry 37: 17137-17144. PMID 9860826.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.