Lizofosfatidilholin

Izvor: Wikipedia
Generalna hemijska struktura lizofosfatidilholina, gde je R varijabilni lanac masne kiseline

Lizofosfatidilholini (LPC), ili lizolecitini, su klasa hemijskih jedinjenja koja su izvedena iz fosfatidilholina.[1] Oni proizilaze iz parcijalne hidrolize fosfatidilholina, koja uklanja jednu od grupa masnih kiselina. Hidroliza je generalno rezultat enzimskog dejstva fosfolipaze A2.[2][3][4]

LPC se može koristiti u laboratoriji za izazivanje demijelinacije režnjeva mozga, čime se oponašaju efekti demijelinacionih oboljenja kao što je multipla skleroza..[1][5]

Vidi još[uredi - уреди]

Reference[uredi - уреди]

  1. 1.0 1.1 Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer. ISBN 0-387-36602-4. 
  2. "Phosphatidylcholine and related lipids, lipidlibrary.co.uk". http://www.lipidlibrary.co.uk/Lipids/pc/index.htm. 
  3. Robinson BS, Yao ZM, Baisted DJ, Vance DE (May 1989). "Lysophosphatidylcholine metabolism and lipoprotein secretion by cultured rat hepatocytes deficient in choline". The Biochemical Journal 260 (1): 207–14. PMC 1138647. PMID 2775183. Retrieved 2011-04-10. 
  4. Illingworth DR, Portman OW (November 1972). "The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys". The Biochemical Journal 130 (2): 557–67. PMC 1174436. PMID 4198083. Retrieved 2011-04-10. 
  5. Degaonkar MN, Raghunathan P, Jayasundar R, Jagannathan NR (January 2005). "Determination of relaxation characteristics during preacute stage of lysophosphatidyl choline-induced demyelinating lesion in rat brain: an animal model of multiple sclerosis". Magnetic Resonance Imaging 23 (1): 69–73. doi:10.1016/j.mri.2004.11.010. PMID 15733790. Retrieved 2011-04-10. 

Literatura[uredi - уреди]

  • Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer.