Lizofosfatidilholin
Lizofosfatidilholini (LPC), ili lizolecitini, su klasa hemijskih jedinjenja koja su izvedena iz fosfatidilholina.[1] Oni proizilaze iz parcijalne hidrolize fosfatidilholina, koja uklanja jednu od grupa masnih kiselina. Hidroliza je generalno rezultat enzimskog dejstva fosfolipaze A2.[2][3][4]
LPC se može koristiti u laboratoriji za izazivanje demijelinacije režnjeva mozga, čime se oponašaju efekti demijelinacionih oboljenja kao što je multipla skleroza..[1][5]
- ↑ 1,0 1,1 Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer. ISBN 0-387-36602-4.
- ↑ „Phosphatidylcholine and related lipids, lipidlibrary.co.uk”.
- ↑ Robinson BS, Yao ZM, Baisted DJ, Vance DE (May 1989). „Lysophosphatidylcholine metabolism and lipoprotein secretion by cultured rat hepatocytes deficient in choline”. The Biochemical Journal 260 (1): 207–14. PMC 1138647. PMID 2775183. Pristupljeno 2011-04-10.
- ↑ Illingworth DR, Portman OW (November 1972). „The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys”. The Biochemical Journal 130 (2): 557–67. PMC 1174436. PMID 4198083. Pristupljeno 2011-04-10.
- ↑ Degaonkar MN, Raghunathan P, Jayasundar R, Jagannathan NR (January 2005). „Determination of relaxation characteristics during preacute stage of lysophosphatidyl choline-induced demyelinating lesion in rat brain: an animal model of multiple sclerosis”. Magnetic Resonance Imaging 23 (1): 69–73. DOI:10.1016/j.mri.2004.11.010. PMID 15733790. Pristupljeno 2011-04-10.
- Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer.