Leukotrien-B4 20-monooksigenaza
(Preusmjereno sa stranice LTB4 omega-hidroksilaza)
| Leukotrien-B4 20-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.30 | ||||||||
| CAS broj | 90119-11-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Leukotrien-B4 20-monooksigenaza (EC 1.14.13.30, leukotrien-B4 20-hidroksilaza, leukotrien-B4 omega-hidroksilaza, LTB4 20-hidroksilaza, LTB4 omega-hidroksilaza) je enzim sa sistematskim imenom (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihidroksiikosa-6,8,10,14-tetraenoat,NADPH:kiseonik oksidoreduktaza (20-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihidroksiikosa-6,8,10,14-tetraenoat + NADPH + H+ + O2 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihidroksiikosa-6,8,10,14-tetraenoat + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450).
Reference[uredi | uredi kod]
- ↑ Romano, M.C., Eckardt, R.D., Bender, P.E., Leonard, T.B., Straub, K.M. and Newton, J.F. (1987). „Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases”. J. Biol. Chem. 262: 1590-1595. PMID 3027095.
- ↑ Shak, S. and Goldstein, I.M. (1985). „Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450”. J. Clin. Invest. 76: 1218-1228. PMID 4044832.
- ↑ Soberman, R.J., Harper, T.W., Murphy, R.C. and Austen, K.F. (1985). „Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes”. Proc. Natl Acad. Sci. USA 82: 2292-2295. PMID 2986111.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.