L-peptidaza
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| L-peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.46 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-peptidaza (EC 3.4.22.46, L-peptidase) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Autokatalitičko odvajanje od poliproteina virusa bolesti slinavka i šap putem hidrolize Lys-Gly veze. Zatim razlaže initiation faktor eIF-4G ćelije domaćina na vezama -Gly-Arg- i -Lys-Arg-
Ovaj enzim je najpoznatiji po virusu bolesti slinavke i šapa.
Reference[uredi | uredi kod]
- ↑ Piccone, M.E., Zellner, M., Kumosinski, T.F., Mason, P.W. and Grubman, M.J. (1995). „Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus”. J. Virol. 69: 4950-4956. PMID 7609064.
- ↑ Guarné, A., Hampoelz, B., Glaser, W., Carpena, X., Torma, J., Fita, I. and Skern, T. (2000). „Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes”. J. Mol. Biol. 302: 1227-1240. PMID 11183785.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.