L-metionin (S)-S-oksid reduktaza
| L-metionin (S)-S-oksid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.4.13 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-metionin (S)-S-oksid reduktaza (EC 1.8.4.13, fSMsr, metil sulfoksid reduktaza I i II, acetilmetionin sulfoksidna reduktaza, metionin sulfoksidna reduktaza, L-metionin:oksidovani-tioredoksin S-oksidoreduktaza, metionin-S-oksidna reduktaza, free-metionin (S)-S-oksidna reduktaza) je enzim sa sistematskim imenom L-metionin:tioredoksin-disulfid S-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-metionin + tioredoksin disulfid +H2O L-metionin (S)-S-oksid + tioredoksin
Za rad ovog enzima je neophodan NADPH. Reakcija se odvija u reverznom smeru.
- ↑ Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. (1960). „A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides”. J. Biol. Chem. 235: 2910-2916.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1979). „Reduction of methionine sulfoxide to methionine by Escherichia coli”. J. Bacteriol. 139: 161-164. PMID 37234.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1980). „The purification of methionine sulfoxide reductase from Escherichia coli”. Anal. Biochem. 102: 393-398. PMID 6999943.
- ↑ Weissbach, H., Resnick, L. and Brot, N. (2005). „Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage”. Biochim. Biophys. Acta 1703: 203-212. PMID 15680228.
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