L-galaktoza 1-dehidrogenaza
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| L-galaktoza 1-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.316 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-galaktoza 1-dehidrogenaza (EC 1.1.1.316, L-GalDH, L-galaktozna dehidrogenaza) je enzim sa sistematskim imenom L-galaktoza:NAD+ 1-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-galaktoza + NAD+ L-galakto-1,4-lakton + NADH + H+
Ovaj enzim katalizuje korak u askorbatnoj biosintezi kod viših biljki (Smirnof-Vilerov put). Njegova aktivnost sa NADP+ je manje od 10% njegove aktivnosti sa NAD+.
Reference[uredi | uredi kod]
- ↑ Mieda, T., Yabuta, Y., Rapolu, M., Motoki, T., Takeda, T., Yoshimura, K., Ishikawa, T. and Shigeoka, S. (2004). „Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate”. Plant Cell Physiol. 45: 1271-1279. PMID 15509850.
- ↑ Gatzek, S., Wheeler, G.L. and Smirnoff, N. (2002). „Antisense suppression of L-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated L-galactose synthesis”. Plant J. 30: 541-553. PMID 12047629.
- ↑ Wheeler, G.L., Jones, M.A. and Smirnoff, N. (1998). „The biosynthetic pathway of vitamin C in higher plants”. Nature 393: 365-369. PMID 9620799.
- ↑ Oh, M.M., Carey, E.E. and Rajashekar, C.B. (2009). „Environmental stresses induce health-promoting phytochemicals in lettuce”. Plant Physiol. Biochem. 47: 578-583. PMID 19297184.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.