Aminopeptidaza I
(Preusmjereno sa stranice Kvaščana aminopeptidaza I)
| Aminopeptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.22 | ||||||||
| CAS broj | 9031-94-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminopeptidaza I (EC 3.4.11.22, aminopeptidaza III, aminopeptidaza yscI, leucinska aminopeptidaza IV, kvaščana aminopeptidaza I) je enzim sa sistematskim imenom '.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne aminokiseline, preferentno neutralne ili hidrofobne, sa polipeptida. Aminoacil-arilamidi su slabi supstrati
Ovaj 640 kDa težak dodekamerni enzim je najpoznatiji kao glavna vakuolarna aminopeptidaza kod kvasca.
- ↑ Johnson, M.J. (1941). „Isolation and properties of a pure yeast polypeptidase”. J. Biol. Chem. 137: 575-586.
- ↑ Metz, G. and Rohm, K.-H. (1976). „Yeast aminopeptidase I. Chemical composition and catalytic properties”. Biochim. Biophys. Acta 429: 933-949. PMID 5147.
- ↑ Chang, Y-H. and Smith, J.A. (1989). „Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae”. J. Biol. Chem. 264: 6979-6983. PMID 2651436.
- ↑ Oda, M.N., Scott, S.V., Hefner-Gravink, A., Caffarelli, A.D. and Klionsky, D.J. (1996). „Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I”. J. Cell Biol. 132: 999-1010. PMID 8601598.
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