Krotonil-KoA karboksilaza/reduktaza
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| Krotonil-KoA karboksilaza/reduktaza | |||||||||
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| Krotonil-KoA karboksilaza/reduktaza tetramer, Streptomyces sp. NRRL 2288 | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.1.85 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Krotonil-KoA karboksilaza/reduktaza (EC 1.3.1.85, CCR, krotonil-KoA reduktaza (karboksilating)) je enzim sa sistematskim imenom (2S)-etilmalonil-KoA:NADP+ oksidoreduktaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S)-etilmalonil-KoA + NADP+ (E)-but-2-enoil-KoA + CO2 + NADPH + H+
Ova reakcija je katalizovana u reverznom smeru. Enzim, izolovan iz bakterije Rhodobacter sphaeroides, katalizuje (E)-but-2-enoil-KoA-zavisnu oksidaciju NADPH u prisustvu CO2.
Reference[uredi | uredi kod]
- ↑ Erb, T.J., Berg, I.A., Brecht, V., Muller, M., Fuchs, G. and Alber, B.E. (2007). „Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway”. Proc. Natl. Acad. Sci. USA 104: 10631-10636. PMID 17548827.
- ↑ Erb, T.J., Brecht, V., Fuchs, G., Muller, M. and Alber, B.E. (2009). „Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase”. Proc. Natl. Acad. Sci. USA 106: 8871-8876. PMID 19458256.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.