Komponenta komplementa 2

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Komponenta komplementa 2
PDB prikaz baziran na 2i6q.
Dostupne strukture
2i6q, 2i6s, 2odp, 2odq
Identifikatori
Simboli	C2; CO2; DKFZp779M0311
Vanjski ID	OMIM: 217000 MGI: 88226 HomoloGene: 45 GeneCards: C2 Gene
Ontologija gena Molekularna funkcija • aktivnost klasičnog komplementnog puta C3/C5 konvertaze • aktivnost serinskog-tipa endopeptidaze • aktivnost peptidaze Celularna komponenta • ekstracelularni region • kompleks komponente komplementa C2 Biološki proces • proteoliza • aktivacija komplementa, klasični put • urođeni imunski respons
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	717	12263
Ensembl	ENSG00000166278	ENSMUSG00000024372
UniProt	P06681	O70350
RefSeq (mRNA)	NM_000063	NM_013484
RefSeq (protein)	NP_000054	NP_038512
Lokacija (UCSC)	Chr c6_COX: 32.03 - 32.05 Mb	Chr 17: 34.47 - 34.49 Mb
PubMed pretraga	[1]	[2]

Komponenta komplementa C2 je protein koji je kod čoveka kodiran C2 genom. Ovaj protein je deo klasičnog puta sistema komplementa.

Aktivirani C1 razlaže C2 u C2a i C2b. C2a dovodi do aktivacije C3. C2 deficijencija je povezana sa pojedinim autoimunskim oboljenjima.

Literatura

• Bartholomew WR, Shanahan TC (1991). „Complement components and receptors: deficiencies and disease associations.”. Immunol. Ser. 52: 33–51. PMID 2091785. 
• Campbell RD (1988). „The molecular genetics and polymorphism of C2 and factor B.”. Br. Med. Bull. 43 (1): 37–49. PMID 3315100. 
• Yu CY (1999). „Molecular genetics of the human MHC complement gene cluster.”. Exp. Clin. Immunogenet. 15 (4): 213–30. DOI:10.1159/000019075. PMID 10072631. 
• Lutsenko SM, Kharchenko VG, Bachurin VI, Lomakin MM (1976). „[Circulating blood volume and regional hemodynamics in acute gastrointestinal hemorrhage]”. Sovetskaia meditsina (2): 38–41. PMID 1084023. 
• Zhu ZB, Hsieh SL, Bentley DR, et al. (1992). „A variable number of tandem repeats locus within the human complement C2 gene is associated with a retroposon derived from a human endogenous retrovirus.”. J. Exp. Med. 175 (6): 1783–7. DOI:10.1084/jem.175.6.1783. PMC 2119228. PMID 1350302. 
• Lappin DF, Guc D, Hill A, et al. (1992). „Effect of interferon-gamma on complement gene expression in different cell types.”. Biochem. J. 281 ( Pt 2): 437–42. PMC 1130704. PMID 1531292. 
• Johnson CA, Densen P, Hurford RK, et al. (1992). „Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing.”. J. Biol. Chem. 267 (13): 9347–53. PMID 1577763. 
• Lappin DF, Birnie GD, Whaley K (1991). „Interferon-mediated transcriptional and post-transcriptional modulation of complement gene expression in human monocytes.”. Eur. J. Biochem. 194 (1): 177–84. DOI:10.1111/j.1432-1033.1990.tb19443.x. PMID 1701385. 
• Horiuchi T, Macon KJ, Kidd VJ, Volanakis JE (1989). „cDNA cloning and expression of human complement component C2.”. J. Immunol. 142 (6): 2105–11. PMID 2493504. 
• Cole FS, Whitehead AS, Auerbach HS, et al. (1985). „The molecular basis for genetic deficiency of the second component of human complement.”. N. Engl. J. Med. 313 (1): 11–6. DOI:10.1056/NEJM198507043130103. PMID 2582254. 
• Bentley DR (1987). „Primary structure of human complement component C2. Homology to two unrelated protein families.”. Biochem. J. 239 (2): 339–45. PMC 1147286. PMID 2949737. 
• Bentley DR, Campbell RD, Cross SJ (1985). „DNA polymorphism of the C2 locus.”. Immunogenetics 22 (4): 377–90. DOI:10.1007/BF00430921. PMID 2997031. 
• Kam CM, McRae BJ, Harper JW, et al. (1987). „Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.”. J. Biol. Chem. 262 (8): 3444–51. PMID 3546307. 
• Wu LC, Morley BJ, Campbell RD (1987). „Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements.”. Cell 48 (2): 331–42. DOI:10.1016/0092-8674(87)90436-3. PMID 3643061. 
• Gagnon J (1984). „Structure and activation of complement components C2 and factor B.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306 (1129): 301–9. DOI:10.1098/rstb.1984.0091. PMID 6149575. 
• Bentley DR, Porter RR (1984). „Isolation of cDNA clones for human complement component C2.”. Proc. Natl. Acad. Sci. U.S.A. 81 (4): 1212–5. DOI:10.1073/pnas.81.4.1212. PMC 344796. PMID 6199794. 
• Parkes C, Gagnon J, Kerr MA (1983). „The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group.”. Biochem. J. 213 (1): 201–9. PMC 1152109. PMID 6555044. 
• Kerr MA, Gagnon J (1982). „The purification and properties of the second component of guinea-pig complement.”. Biochem. J. 205 (1): 59–67. PMC 1158446. PMID 6922702. 

Spoljašnje veze

• MeSH Complement+2