Kokainska estaraza
Prijeđi na navigaciju
Prijeđi na pretragu
| Kokainska estaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.84 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kokainska estaraza (EC 3.1.1.84, CocE, hCE2, hCE-2, human karboksilesteraza 2) je enzim sa sistematskim imenom kokain benzoilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Rhodococcus vrsta MB1 i Pseudomonas maltophilia vrsta MB11L mogu da koriste kokain kao jedini izvor ugljenika i energije.
Reference[uredi | uredi kod]
- ↑ Gao, D., Narasimhan, D.L., Macdonald, J., Brim, R., Ko, M.C., Landry, D.W., Woods, J.H., Sunahara, R.K. and Zhan, C.G. (2009). „Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity”. Mol. Pharmacol. 75: 318-323. PMID 18987161.
- ↑ Bresler, M.M., Rosser, S.J., Basran, A. and Bruce, N.C. (2000). „Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1”. Appl. Environ. Microbiol. 66: 904-908. PMID 10698749.
- ↑ Britt, A.J., Bruce, N.C. and Lowe, C.R. (1992). „Identification of a cocaine esterase in a strain of Pseudomonas maltophilia”. J. Bacteriol. 174: 2087-2094. PMID 1551831.
- ↑ Larsen, N.A., Turner, J.M., Stevens, J., Rosser, S.J., Basran, A., Lerner, R.A., Bruce, N.C. and Wilson, I.A. (2002). „Crystal structure of a bacterial cocaine esterase”. Nat. Struct. Biol. 9: 17-21. PMID 11742345.
- ↑ Pindel, E.V., Kedishvili, N.Y., Abraham, T.L., Brzezinski, M.R., Zhang, J., Dean, R.A. and Bosron, W.F. (1997). „Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin”. J. Biol. Chem. 272: 14769-14775. PMID 9169443.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.