Katalaza-peroksidaza
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| Katalaza-peroksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.21 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Katalaza-peroksidaza (EC 1.11.1.21, katG (gen)) je enzim sa sistematskim imenom donor:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) donor + H2O2 oksidovani donor + 2 H2O
- (2) 2 H2O2 O2 + 2 H2O
Ovaj enzim se razlikuje od EC 1.11.1.7 peroksidaze po tome što ima relativno jako katalazno dejstvo sa H2O2 kao donorom, pri čemu se formira O2.
Reference[uredi | uredi kod]
- ↑ Loewen, P.C., Triggs, B.L., George, C.S. and Hrabarchuk, B.E. (1985). „Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli”. J. Bacteriol. 162: 661-667. PMID 3886630.
- ↑ Hochman, A. and Goldberg, I. (1991). „Purification and characterization of a catalase-peroxidase and a typical catalase from the bacterium Klebsiella pneumoniae”. Biochim. Biophys. Acta 1077: 299-307. PMID 2029529.
- ↑ Fraaije, M.W., Roubroeks, H.P., van Berkel, W.H.J. (1996). „Purification and characterization of an intracellular catalase-peroxidase from Penicillium simplicissimum”. Eur. J. Biochem. 235: 192-198. PMID 8631329.
- ↑ Bertrand, T., Eady, N.A., Jones, J.N., Jesmin, Nagy, J.M., Jamart-Gregoire, B., Raven, E.L. and Brown, K.A. (2004). „Crystal structure of Mycobacterium tuberculosis catalase-peroxidase”. J. Biol. Chem. 279: 38991-38999. PMID 15231843.
- ↑ Vlasits, J., Jakopitsch, C., Bernroitner, M., Zamocky, M., Furtmuller, P.G. and Obinger, C. (2010). „Mechanisms of catalase activity of heme peroxidases”. Arch. Biochem. Biophys. 500: 74-81. PMID 20434429.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.