Stratum corneum himotriptinski enzim
(Preusmjereno sa stranice KLK7)
| Stratum corneum himotriptinski enzim | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.117 | ||||||||
| CAS broj | 155215-90-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Stratum corneum himotriptinski enzim (EC 3.4.21.117, kalikrein 7, SCCE, KLK7, PRSS6, hK7) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje proteina sa aromatičnim bočnim lacima u P1 poziciji
Ova enzim ima široku supstratnu specifičnost, te može da degradira toplotom-denaturisani goveđi kazein i alfa-lanace prirodnog ljudskog fibrinogena.
Reference[uredi | uredi kod]
- ↑ Skytt, A., Strömqvist, M. and Egelrud, T. (1995). „Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme”. Biochem. Biophys. Res. Commun. 211: 586-589. PMID 7794273.
- ↑ Egelrud, T. (1993). „Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation”. J. Invest. Dermatol. 101: 200-204. PMID 8393902.
- ↑ Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T. (1994). „Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase”. J. Biol. Chem. 269: 19420-19426. PMID 8034709.
- ↑ Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P. (2000). „The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation”. Gene 254: 119-128. PMID 10974542.
- ↑ Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R. (2004). „Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis”. J. Invest. Dermatol. 123: 62-66. PMID 15191543.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.