1,2-Naftohinon

1,2-Naftohinon
Drugi nazivi	o-Naftohinon,; β-naftohinon
Identifikacija
CAS registarski broj	524-42-5
PubChem	10667
ChemSpider	10217
KEGG	C14783
ChEMBL	CHEMBL52347
Jmol-3D slike	Slika 1
SMILES
	O=C1c2ccccc2\C=C/C1=O
InChI
	InChI=1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H ; Kod: KETQAJRQOHHATG-UHFFFAOYSA-N InChI=1/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H; Kod: KETQAJRQOHHATG-UHFFFAOYAZ
Svojstva
Molekulska formula	C10H6O2
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1,2-Naftohinon (orto-naftohinon) je policiklično aromatično organsko jedinjenje.

Ovaj dvostruki keton (hinon) je reaktivni metabolit naftalina, koji je prisutan je u česticama dizelnih izduvnih gasova. Akumulacija ovog toksičnog metabolita izaziva oštećenje očiju kod pacova, uključujući formiranje katarakti.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Qian, W.; Shichi, H. (2001). „Naphthoquinone-Induced Cataract in Mice: Possible Involvement of Ca²⁺ Release and Calpain Activation”. Journal of Ocular Pharmacology and Therapeutics 17 (4): 383–392. DOI:10.1089/108076801753162799. PMID 11572469.

Literatura

Troester, M. A.; Lindstrom, A. B.; Waidyanatha, S.; Kupper, L. L.; Rappaport, S. M. (2002). „Stability of Hemoglobin and Albumin Adducts of Naphthalene Oxide, 1,2-Naphthoquinone, and 1,4-Naphthoquinone” (pdf). Toxicological Sciences 68 (2): 314–321. DOI:10.1093/toxsci/68.2.314. PMID 12151627.
Kikuno, S.; Taguchi, K.; Iwamoto, N. et al. (2006). „1,2-Naphthoquinone Activates Vanilloid Receptor 1 through Increased Protein Tyrosine Phosphorylation, Leading to Contraction of Guinea Pig Trachea”. Toxicology and Applied Pharmacology 210 (1–2): 47–54. DOI:10.1016/j.taap.2005.06.015. PMID 16039679.

Povezano

1,4-Naftohinon, izomer 1,2-naftohinona

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Qian, W.; Shichi, H. (2001). „Naphthoquinone-Induced Cataract in Mice: Possible Involvement of Ca²⁺ Release and Calpain Activation”. Journal of Ocular Pharmacology and Therapeutics 17 (4): 383–392. DOI:10.1089/108076801753162799. PMID 11572469.

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