Jonski kanal
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Šematski prikaz jonskog kanala. 1 - kanalni domeni (tipično četiri po kanalu), 2 - spoljašnja pretkomora, 3 - filter selektivnosti, 4 - dijametar filtera selektivnosti, 5 - mesto fosforilacije, 6 - ćelijska membrana.
Jonski kanali su proteini koji formiraju pore koje pomažu u uspostavljanju i kontroli naponskog gradijenta preko ćelijske membrane (vidi ćelijski potencijal) putem omogućavanja protoka jona niz njihov elektrohemijski gradijent.[1][2] Oni su prisutni u membranama koje okružuju sve biološke ćelije. Studiranje jonskih kanala obuhvata mnoge naučne tehnike kao što su elektrofiziologija naponske spone (posebno slojna spona), imunohistohemija, i RT-PCR.
Reference[uredi - уреди | uredi kôd]
- ↑ Hille, Bertil (2001). Ion Channels of Excitable Membranes (3rd izd.). Sunderland, Mass: Sinauer Associates. ISBN 0-87893-321-2.
- ↑ Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0. http://www.chem.upenn.edu/chem/research/faculty.php?browse=V.
Literatura[uredi - уреди | uredi kôd]
- An Interview with Roderick MacKinnon Freeview video by the Vega Science Trust.
- Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (April 1998). „The structure of the potassium channel: molecular basis of K+ conduction and selectivity”. Science 280 (5360): 69–77. Bibcode 1998Sci...280...69D. DOI:10.1126/science.280.5360.69. PMID 9525859. http://www.cellbio.wustl.edu/faculty/huettner/69.pdf.
- Bezanilla F (April 2000). „The voltage sensor in voltage-dependent ion channels”. Physiol. Rev. 80 (2): 555–92. PMID 10747201. http://physrev.physiology.org/cgi/content/abstract/80/2/555.
- Singh H (2010). „Two decades with dimorphic Chloride Intracellular Channels (CLICs)”. Febs letters. 584 (10): 2112–21. DOI:10.1016/j.febslet.2010.03.013. PMID 20226783.
- Catterall WA (2010). „Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology”. Neuron 67 (6): 915–928. DOI:10.1016/j.neuron.2010.08.021. PMC 2950829. PMID 20869590. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2950829/.
- Kathy Liszewski (15. 6. 2007.). „Opening the Gates on Ion Channel Drugs”. Genetic Engineering & Biotechnology News (Mary Ann Liebert, Inc.): pp. 18, 20. http://www.genengnews.com/articles/chitem.aspx?aid=2159. Pristupljeno 6. 7. 2008. "Conditions targeted include diabetes, cystic fibrosis, hypertension, pain and cancer"
- Shahidul, Islam (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. str. 700. ISBN 978-94-007-0264-6.
- Hille, Bertil (2001). Ion Channels of Excitable Membranes (3rd izd.). Sunderland, Mass: Sinauer Associates.
Vidi još[uredi - уреди | uredi kôd]
Spoljašnje veze[uredi - уреди | uredi kôd]
- „Voltage-Gated Ion Channels”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/DATABASE/ReceptorFamiliesForward?type=IC.
- „TRIP Database”. a manually curated database of protein-protein interactions for mammalian TRP channels. Arhivirano iz originala 2016-08-10. https://web.archive.org/web/20160810025812/http://www.trpchannel.org/.
- AurSCOPE Ion Channels Database Arhivirano 2011-05-06 na Wayback Machine-u
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