Jonski kanal

Šematski prikaz jonskog kanala. 1 - kanalni domeni (tipično četiri po kanalu), 2 - spoljašnja pretkomora, 3 - filter selektivnosti, 4 - dijametar filtera selektivnosti, 5 - mesto fosforilacije, 6 - ćelijska membrana.

Jonski kanali su proteini koji formiraju pore koje pomažu u uspostavljanju i kontroli naponskog gradijenta preko ćelijske membrane (vidi ćelijski potencijal) putem omogućavanja protoka jona niz njihov elektrohemijski gradijent. Oni su prisutni u membranama koje okružuju sve biološke ćelije. Studiranje jonskih kanala obuhvata mnoge naučne tehnike kao što su elektrofiziologija naponske spone (posebno slojna spona), imunohistohemija, i RT-PCR.

Literatura

• An Interview with Roderick MacKinnon Freeview video by the Vega Science Trust.
• Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (April 1998). "The structure of the potassium channel: molecular basis of K+ conduction and selectivity" (PDF). Science 280 (5360): 69–77. Bibcode:1998Sci...280...69D. PMID 9525859. doi:10.1126/science.280.5360.69. 
• Bezanilla F (April 2000). "The voltage sensor in voltage-dependent ion channels". Physiol. Rev. 80 (2): 555–92. PMID 10747201. 
• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". Febs letters. 584 (10): 2112–21. PMID 20226783. doi:10.1016/j.febslet.2010.03.013. 
• Catterall WA (2010). "Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology". Neuron 67 (6): 915–928. PMC 2950829. PMID 20869590. doi:10.1016/j.neuron.2010.08.021. 
• Kathy Liszewski (15. 6. 2007.). "Opening the Gates on Ion Channel Drugs". Genetic Engineering & Biotechnology News (Mary Ann Liebert, Inc.). pp. 18, 20. Pristupljeno 6. 7. 2008.. Conditions targeted include diabetes, cystic fibrosis, hypertension, pain and cancer 
• Shahidul, Islam (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. str. 700. ISBN 978-94-007-0264-6. 
• Hille, Bertil (2001). Ion Channels of Excitable Membranes (3rd izd.). Sunderland, Mass: Sinauer Associates. 

Vidi još

• Akcioni potentijal
• Aktivni transport
• Alfa heliks
• Elektrohemijski gradient
• Membranski potencijal
• Membranski receptor
• Neurotoksin
• Pasivni trasport

Spoljašnje veze

• "Voltage-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/DATABASE/ReceptorFamiliesForward?type=IC. 
• "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels. http://www.trpchannel.org. 
• AurSCOPE Ion Channels Database