Purinska nukleozidaza
(Preusmjereno sa stranice IAG-nucleoside hydrolase)
Purinska nukleozidaza | |||||||||
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Purinska nukleozidaza tetramer, Saccharolobus solfataricus | |||||||||
Identifikatori | |||||||||
EC broj | 3.2.2.1 | ||||||||
CAS broj | 9025-44-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Purinska nukleozidaza (EC 3.2.2.1, nukleozidaza, purin beta-ribozidaza, purin nukleozidna hidrolaza, purinska ribonukleozidaza, ribonukleozidna hidrolaza, nukleozidna hidrolaza, N-ribozil purinska ribohidrolaza, nukleozidaza g, N-D-ribozilpurinska ribohidrolaza, inozin-adenozin-guanozin preferentna nukleozidna hidrolaza, purin-specifična nukleozidna N-ribohidrolaza, IAG-nukleozidna hidrolaza, IAG-NH) je enzim sa sistematskim imenom purin-nukleozidna ribohidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- purinski nukleozid + H2O D-riboza + purinska baza
Enzim iz bakterije Ochrobactrum anthropi specifično katalizuje ireverzibilnu N-ribozidnu hidrolizu purinskih nukleozida.
Reference[uredi | uredi kod]
- ↑ Heppel, L.A. and Hilmoe, R.J. (1952). „Phosphorolysis and hydrolysis of purine ribosides from yeast”. J. Biol. Chem. 198: 683-694. PMID 12999785.
- ↑ Kalckar, H.M. (1951). „Biosynthetic aspects of nucleosides and nucleic acids”. Pubbl. Staz. Zool. (Napoli) 23: 87-103.
- ↑ Takagi, Y. and Horecker, B.L. (1956). „Purification and properties of a bacterial riboside hydrolyase”. J. Biol. Chem. 225: 77-86. PMID 13416219.
- ↑ Tarr, H.L.A. (1955). „Fish muscle riboside hydrolases”. Biochem. J. 59: 386-391. PMID 14363106.
- ↑ Parkin, D.W. (1996). „Purine-specific nucleoside N-ribohydrolase from 'Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism”. J. Biol. Chem. 271: 21713-21719. PMID 8702965.
- ↑ Ogawa, J., Takeda, S., Xie, S.X., Hatanaka, H., Ashikari, T., Amachi, T. and Shimizu, S. (2001). „Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi”. Appl. Environ. Microbiol. 67: 1783-1787. PMID 11282633.
- ↑ Versées, W., Decanniere, K., Van Holsbeke, E., Devroede, N. and Steyaert, J. (2002). „Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax”. J. Biol. Chem. 277: 15938-15946. PMID 11854281.
- ↑ Mazumder-Shivakumar, D. and Bruice, T.C. (2005). „Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues”. Biochemistry 44: 7805-7817. PMID 15909995.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.