HslU-HslV peptidaza

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HslU-HslV peptidaza
HslU-HslV peptidaza dodekamer, E.Coli
EC broj
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile

HslU-HslV peptidaza (EC, HslUV, HslV-HslU, HslV peptidaza, ATP-zavisna HslV-HslU proteinaza, kazeinolitička proteaza X, kazeinolitička proteinaza X, ClpXP ATP-zavisna proteaza, ClpXP proteaza, ClpXP serinska proteinaza, Escherichia coli ClpXP serinska proteinaza, HslUV proteaza, HslUV proteinaza, HslVU proteaza, HslVU proteinaza, proteaza HslVU, proteinaza HslUV) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP-zavisno razlaganje peptidnih veza sa širokom specifičnošću

Ovaj enzim pripada peptidaznoj familiji T1.


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  1. Wang, J., Rho, S.H., Park, H.H. and Eom, S.H. (2005). „Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects”. Acta Crystallogr. D Biol. Crystallogr. 61: 932-941. PMID 15983416. 
  2. Nishii, W. and Takahashi, K. (2003). „Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli”. FEBS Lett. 553: 351-354. PMID 14572649. 
  3. Ramachandran, R., Hartmann, C., Song, H.K., Huber, R. and Bochtler, M. (2002). „Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)”. Proc. Natl. Acad. Sci. USA 99: 7396-7401. PMID 12032294. 
  4. Yoo, S.J., Seol, J.H., Shin, D.H., Rohrwild, M., Kang, M.S., Tanaka, K., Goldberg, A.L. and Chung, C.H. (1996). „Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli”. J. Biol. Chem. 271: 14035-14040. PMID 8662828. 
  5. Yoo, S.J., Seol, J.H., Seong, I.S., Kang, M.S. and Chung, C.H. (1997). „ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli”. Biochem. Biophys. Res. Commun. 238: 581-585. PMID 9299555. 
  6. Kanemori, M., Nishihara, K., Yanagi, H. and Yura, T. (1997). „Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of σ32 and abnormal proteins in Escherichia coli. J. Bacteriol. 179: 7219-7225. PMID 9393683. 
  7. Burton, R.E., Baker, T.A. and Sauer, R.T. (2005). „Nucleotide-dependent substrate recognition by the AAA+ HslUV protease”. Nat. Struct. Mol. Biol. 12: 245-251. PMID 15696175. 


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