Hinin 3-monooksigenaza
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| Hinin 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.67 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hinin 3-monooksigenaza (EC 1.14.13.67, hininska 3-hidroksilaza) je enzim sa sistematskim imenom hinin,NADPH:kiseonik oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hinin + NADPH + H+ + O2 3-hidroksihinin + NADP+ + H2O
Reference[uredi | uredi kod]
- ↑ Relling, M.V., Evans, R., Dass, C., Desiderio, D.M. and Nemec, J. (1992). „Human cytochrome P450 metabolism of teniposide and etoposide”. J. Pharmacol. Exp. Ther. 261: 491-496. PMID 1578365.
- ↑ Zhang, H., Coville, P.F., Walker, R.J., Miners, J.O., Birkett, D.J. and Wanwimolruk, S. (1997). „Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine”. Br. J. Clin. Pharmacol. 43: 245-252. PMID 9088578.
- ↑ Zhao, X.-J., Kawashiro, T. and Ishizaki, T. (1998). „Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways”. Drug Metab. Dispos. 26: 188-191. PMID 9456308.
- ↑ Zhao, X.-J., Yokoyama, H., Chiba, K., Wanwimolruk, S. and Ishizaki, T. (1996). „Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450”. J. Pharmacol. Exp. Ther. 279: 1327-1334. PMID 8968357.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.