Hidrolaza nezasićenog hondroitinskog disaharida
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| Hidrolaza nezasićenog hondroitinskog disaharida | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.180 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hidrolaza nezasićenog hondroitinskog disaharida (EC 3.2.1.180, UGL, hidrolaza nezasićenog glukuronila) je enzim sa sistematskim imenom beta-D-4-dezoksi-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- beta-D-4-dezoksi-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O 5-dehidro-4-dezoksi-D-glukuronat + N-acetil-beta-D-galaktozamin-6-O-sulfat
Ovaj enzim odvaja 4-dezoksi-4,5-didehidro D-glukuronsku kiselinu ili 4-dezoksi-4,5-didehidro L-iduronsku kiselinu sa hondroitin disaharida, hijaluronan disaharida i heparin disaharida.
Reference[uredi | uredi kod]
- ↑ Maruyama, Y., Nakamichi, Y., Itoh, T., Mikami, B., Hashimoto, W. and Murata, K. (2009). „Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan”. J. Biol. Chem. 284: 18059-18069. PMID 19416976.
- ↑ Nakamichi, Y., Maruyama, Y., Mikami, B., Hashimoto, W. and Murata, K. (2011). „Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups”. J. Biol. Chem. 286: 6262-6271. PMID 21147778.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.