Heparanaza

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Heparanaza
Identifikatori
EC broj 3.2.1.166
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Heparanaza (EC 3.2.1.166, Hpa1 heparanaza, Hpa1, heparanaza 1, heparanaza-1, C1A heparanaza, HPSE) je enzim sa sistematskim imenom heparan sulfat N-sulfo-D-glukozamin endoglukanaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

endohidroliza (1->4)-beta-D-glikozidnih veza heparan sulfatnih lanaca u heparan sulfatnom proteoglikanu

Heparanaza razlaže veze između glukuronsko kiselinskih jedinica i N-sulfo glukozaminskih jedinica koje nose bilo 3-O-sulfo ili 6-O-sulfo grupe.

Reference[uredi - уреди | uredi izvor]

  1. Bame, K.J. (2001). "Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans". Glycobiology 11: 91R–98R. PMID 11445547. 
  2. Peterson, S.B. and Liu, J. (2010). "Unraveling the specificity of heparanase utilizing synthetic substrates". J. Biol. Chem. 285: 14504–14513. PMID 20181948. 
  3. Pikas, D.S., Li, J.P., Vlodavsky, I. and Lindahl, U. (1998). "Substrate specificity of heparanases from human hepatoma and platelets". J. Biol. Chem. 273: 18770–18777. PMID 9668050. 
  4. Okada, Y., Yamada, S., Toyoshima, M., Dong, J., Nakajima, M. and Sugahara, K. (2002). "Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence". J. Biol. Chem. 277: 42488–42495. PMID 12213822. 
  5. Vreys, V. and David, G. (2007). "Mammalian heparanase: what is the message". J. Cell. Mol. Med. 11: 427–452. PMID 17635638. 
  6. Gong, F., Jemth, P., Escobar Galvis, M.L., Vlodavsky, I., Horner, A., Lindahl, U. and Li, J.P. (2003). "Processing of macromolecular heparin by heparanase". J. Biol. Chem. 278: 35152–35158. PMID 12837765. 
  7. Toyoshima, M. and Nakajima, M. (1999). "Human heparanase. Purification, characterization, cloning, and expression". J. Biol. Chem. 274: 24153–24160. PMID 10446189. 
  8. Miao, H.Q., Navarro, E., Patel, S., Sargent, D., Koo, H., Wan, H., Plata, A., Zhou, Q., Ludwig, D., Bohlen, P. and Kussie, P. (2002). "Cloning, expression, and purification of mouse heparanase". Protein Expr. Purif. 26: 425–431. PMID 12460766. 
  9. Hammond, E., Li, C.P. and Ferro, V. (2010). "Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening". Anal. Biochem. 396: 112–116. PMID 19748475. 

Literatura[uredi - уреди | uredi izvor]

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