3a(17b)-hidroksisteroid dehidrogenaza (NAD+)
(Preusmjereno sa stranice HSD17B8 (gene name))
| 3a(17b)-hidroksisteroid dehidrogenaza (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.239 | ||||||||
| CAS broj | 126469-82-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3a(17b)-hidroksisteroid dehidrogenaza (NAD+) (EC 1.1.1.239, 3alfa,17beta-hidroksi steroid dehidrogenaza, 3alfa(17beta)-HSD, 17-ketoreduktaza (ambiguous), 17beta-HSD, HSD17B6, HSD17B8) je enzim sa sistematskim imenom 3alfa(or 17beta)-hidroksisteroid:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- testosteron + NAD+ androstendion + NADH + H+
Reference[uredi | uredi kod]
- ↑ Sweat, M.L., Samuels, L.T. and Lumry, R. (1950). „Preparation and characterisation of the enzyme which converts testosterone to androstendione”. J. Biol. Chem. 185: 75-84. PMID 15436478.
- ↑ Villee, C.A. and Spencer, J.M. (1960). „Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 3615-3619. PMID 13781425.
- ↑ Endahl, G.L., Kochakia, C.D. and Hamm, D. (1960). „Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 2792-2796. PMID 13696735.
- ↑ Ohmura, M., Hara, A., Nakagawa, M. and Sawada, H. (1990). „Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver”. Biochem. J. 266: 583-589. PMID 2317205.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.