Kokainska estaraza
(Preusmjereno sa stranice HCE-2)
| Kokainska estaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.84 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kokainska estaraza (EC 3.1.1.84, CocE, hCE2, hCE-2, human karboksilesteraza 2) je enzim sa sistematskim imenom kokain benzoilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Rhodococcus vrsta MB1 i Pseudomonas maltophilia vrsta MB11L mogu da koriste kokain kao jedini izvor ugljenika i energije.
- ↑ Gao, D., Narasimhan, D.L., Macdonald, J., Brim, R., Ko, M.C., Landry, D.W., Woods, J.H., Sunahara, R.K. and Zhan, C.G. (2009). „Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity”. Mol. Pharmacol. 75: 318-323. PMID 18987161.
- ↑ Bresler, M.M., Rosser, S.J., Basran, A. and Bruce, N.C. (2000). „Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1”. Appl. Environ. Microbiol. 66: 904-908. PMID 10698749.
- ↑ Britt, A.J., Bruce, N.C. and Lowe, C.R. (1992). „Identification of a cocaine esterase in a strain of Pseudomonas maltophilia”. J. Bacteriol. 174: 2087-2094. PMID 1551831.
- ↑ Larsen, N.A., Turner, J.M., Stevens, J., Rosser, S.J., Basran, A., Lerner, R.A., Bruce, N.C. and Wilson, I.A. (2002). „Crystal structure of a bacterial cocaine esterase”. Nat. Struct. Biol. 9: 17-21. PMID 11742345.
- ↑ Pindel, E.V., Kedishvili, N.Y., Abraham, T.L., Brzezinski, M.R., Zhang, J., Dean, R.A. and Bosron, W.F. (1997). „Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin”. J. Biol. Chem. 272: 14769-14775. PMID 9169443.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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